T. Olariu, I. Olariu, I. R. Toma, D. G. Negru, E. D. Popovici
Tuesday 10 April 2018 by lib_admin

References: 5th International Multidisciplinary Scientific Conference on Social Sciences and Arts SGEM 2018, www.sgemvienna.org, SGEM2018 Vienna ART Conference Proceedings, ISBN 978-619-7408-32-4 / ISSN 2367-5659, 19 - 21 March, 2018, Vol. 5, Issue 3.1; 571-578 pp, DOI: 10.5593/sgemsocial2018H/31/S13.072


Antimicrobial resistance is a serious threat to global public health and requires action across all government sectors and society. The European Centre for Disease Prevention and Control (ECDC), an EU agency, monitors 52 communicable diseases, having programmes which cover antimicrobial resistance. The highest rates of non prescription use of antibiotics are in Romania (20%). Objectives: To determine if there is any significant difference between antimicrobial resistance of Gram negative bacteria isolated in hospital settings in comparison with those found in ambulatory settings. Materials and Methods: We performed a systematic review and meta-analysis of unpublished studies (as reports that are produced by all levels of government, academics, business and industry in print and electronic formats but that are not controlled by commercial publishers) of Gram negativ bacteria’s antimicrobial resistance in Arad County (n=17.166, between 2010-2016). As for factor analysis we extracted six factors, labeled as: „Total Gram negative isolates”, „Hospital Gram negative antibiotic resistant isolates”, „Ambulatory Gram negative antibiotic resistant isolates”, „Relative Risk”, „Risk Difference” and „Odds ratio” for hospital versus ambulatory bacteria’s antimicrobial resistance. Results: The highest incidence for antimicrobial resistance was in 2011 (41,9% in hospitals and 20,91% in ambulatory settings). Gram negative hospitals bacteria would be 1,493 - 3,544 times as likely as Gram negative ambulatory bacteria to develop antimicrobial resistance isolates and Odds ratio (OR) has had a range of values between 1,36-4,16. Conclusion: Because antimicrobial resistance is endemic both in hospital and ambulatory settings, education programmes are needed for health professional as well as for all Romanian citizens. Recommendation: To limit antibiotic availability for consumption without prescription.

Keywords: antimicrobial resistance, Gram negative bacteria, forest plot, meta-analysis

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